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These immune cell are typically associated with controlling inflammation, but this research shows that they also directly trigger stem cells in the skin to promote healthy hair growth. This means that if the T cells are faulty, it disrupts the ability of the stem cells to regenerate hair follicles and therefore leads to balding. Why they may be faulty, however, remains to be seen. “Our hair follicles are constantly recycling: when a hair falls out, a portion of the hair follicle has to grow back,” Michael Rosenblum , an assistant professor of dermatology at UCSF and senior author, said in a statement . “This has been thought to be an entirely stem cell-dependent process, but it turns out Tregs are essential. If you knock out this one immune cell type, hair just doesn’t grow.” In their study, published in the journal Cell, they conducted experiments that temporarily removed Tregs from the skin of mice. When they shaved the hair off these mice, it didn’t grow back. “We quickly noticed that the shaved patches of hair never grew back, and we thought, ‘Hmm, now that’s treatment for excessive hair shedding interesting,'" Rosenblum said. “We realized we had to delve into this further.” Imaging techniques showed that the Tregs are closely tied to the stem cells in the hair follicles that help regenerate hair. When the follicles enter their usual cycle of regeneration, the number of Tregs around it triples.
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